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Oct 05,  · Fluticasone nasal spray is a steroid drug that can be purchased overthecounter (or by prescription) for relieving symptoms of sinusitis Flonase is a popular nasal spray that you can spray in each nostril daily for relief of sneezing, runny nose, and congestionMar 25, 08 · Answer The most common overthecounter medications used to treat sinus infections would be your decongestants and antihistamines Decongestants are pills that shrink the mucus membranes that line the nose and sinuses to try to promote better drainage Antihistamines can help dry up some mucus secretionsThe primary goal when treating sinusitis is to decrease the inflammation in the nose and sinus openings to improve sinus drainage This may include a combination of medical treatments Your healthcare provider will treat an infection, if present, and try to reduce the symptoms of a runny or congested nose The management of acute sinusitis is different than the management of chronic sinusitis Do Over The Counter M